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Crystal structure of GSK-3 26-383 bound to Axin 383-435- PDB DOI:  https://doi.org/10.2210/pdb8VMG/pdb
- Classification:  TRANSFERASE/SIGNALING PROTEIN
- Organism(s):  Mus musculus , Homo sapiens
- Expression System:  Escherichia coli BL21(DE3)
- Mutation(s):  No 
- Deposited:  2024-01-13  Released:  2024-08-28 
- Deposition Author(s):  Enos, M.D. , Gavagan, M. , Jameson, N. , Zalatan, J.G. , Weis, W.I.
- Funding Organization(s):  National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot - Method:  X-RAY DIFFRACTION
- Resolution:  2.45 Å
- R-Value Free:  0.230 
- R-Value Work:  0.195 
- R-Value Observed:  0.195 
Starting Model: experimental View more details wwPDB Validation     3D Report   Full Report Ligand Structure Quality Assessment   Structural and functional effects of phosphopriming and scaffolding in the kinase GSK3beta(2024) Sci Signal  - DOI:  https://doi.org/10.1126/scisignal.ado0881
  Explore in 3D :  Structure | Sequence Annotations | Validation Report | Ligand Interaction (ADP) Biological assembly 1 assigned by authors and generated by PISA (software) Biological assembly 2 assigned by authors and generated by PISA (software) Macromolecule Content - Total Structure Weight: 101.72 kDa 
- Atom Count: 6,672 
- Modelled Residue Count: 778 
- Deposited Residue Count: 848 
- Unique protein chains: 2
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Molecule | Chains | Sequence Length | Organism | Details | Image |
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Glycogen synthase kinase-3 beta | , | 364 | | : 0   (PDB Primary Data),   (PDB Primary Data)
| | |     | | Sequence Clusters | | UniProt Group | | | |
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Molecule | Chains | Sequence Length | Organism | Details | Image |
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Axin-1 | , | 60 | | : 0  , 
| | |     |   | | Sequence Clusters | | UniProt Group | | | |
Ligands 8 Unique |
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | | E [auth A] | C H N O P XTWYTFMLZFPYCI-KQYNXXCUSA-N | | Interactions | | TA [auth B] | C H N O S SXGZJKUKBWWHRA-UHFFFAOYSA-N | | Interactions | | Less | O S QAOWNCQODCNURD-UHFFFAOYSA-L | | Interactions | | CA [auth A], N [auth A], R [auth A], W [auth A] | C H O PEDCQBHIVMGVHV-UHFFFAOYSA-N | | Interactions | | Less | C H O LYCAIKOWRPUZTN-UHFFFAOYSA-N | | Interactions | | Less | N O NHNBFGGVMKEFGY-UHFFFAOYSA-N | | Interactions | | Less | Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M | | Interactions | | NA [auth A] | Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N | | Interactions |
Experimental Data- Space Group:  P 6 5 2 2
Length ( Å ) | Angle ( ˚ ) |
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a = 195.585 | α = 90 | b = 195.585 | β = 90 | c = 152.204 | γ = 120 |
Software Name | Purpose |
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Blu-Ice | data collection | XDS | data reduction | pointless | data scaling | Aimless | data scaling | PHENIX | phasing | PHENIX | refinement | Coot | model building |
Structure ValidationView  Full Validation Report Ligand Structure Quality Assessment Deposition data. - Released Date:  2024-08-28 
Funding Organization | Location | Grant Number |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM131747 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM119156 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM007276 |
Revision History (Full details and data files)- Version 1.0: 2024-08-28 Type: Initial release
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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute , National Institute of Allergy and Infectious Diseases , and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198. Builder with passion for perfection Whether you are looking for a custom made yacht, a yacht in the line of exciting brands that we build or a thorough refit of your present yacht: come and have a look at our inspiring projects. We’re always eager to tell you more about them! Baruna of 1938Bestevaer 50 StormvogelSpirit of VenicePuffin 50 JaleoChaser 500CCSaloon boat SallyTaeke HadewychRoyal Huisman 64 YonderSaloon boat Proost van Sint JanIJver (IJver Class)Puffin 50 SeaBearGrand Estime 62 MishaPuffin 37 HaaksAgile 42 KarmaStart your journey here, how can we help you. Send us your inquiries! |
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Funding Organization Location Grant Number; National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) United States
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½Evap) and ionized (ionization energy ½Eion) while leaving a vacancy in the metal (vacancy formation energy½Ef).The Mn+ ion was then dissolved into the electrolyte (solvation energy½Esol) while the electrons returned to the metal electrode accord- ing to the reverse of work functionðWf Þ on a zero-charged metal. Therefore, the re-action energyðDE0Þ for each Li and Mg electrodeposition ...
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